게시판
| 21KS-044 |
Analgesic effect of dexmedetomidine in patients undergoing laparoscopic colorectal cancer surgery
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
Background: Despite rapid advancements in laparoscopic surgical devices and techniques, postoperative pain remains a significant clinical issue. We examined analgesic efficacy of intraoperative dexmedetomidine for acute postoperative pain in patients undergoing laparoscopic colorectal cancer surgery.
Methods: We retrospectively analyzed data for 143 patients who had undergone laparoscopic colorectal cancer surgery with intraoperative continuous dexmedetomidine injection (0.5 atients were categorized into the DEX group and non-DEX group, respectively. The demographic, clinical, anesthetic data, and pain at postoperative anesthesia care unit (PACU), 1, 2, and 3 days after surgery were compared between the groups.
Results: A total of 119 patients were enrolled. Demographic and clinical data were not different between the groups. Intraoperatively, mean arterial pressure, heart rate, minimum alveolar concentration of sevoflurane, and fentanyl consumption were significantly lower in DEX group. At PACU, pain score and fentanyl consumption were significantly lower in DEX group. Postoperatively, pain scores and opioid consumptions at 1, 2, and 3 days after surgery were not different between the groups. Time to pass flatus, length of hospital stay, and incidence of nausea/vomiting, and itching were not different between the groups.
Conclusion: Intraoperative continuous dexmedetomidine injection showed intraoperative analgesic effect which was supposed by lower mean arterial pressure, heart rate, minimum alveolar concentration of sevoflurane, and fentanyl consumption. However, it did not have analgesic effect during acute postoperative period except postoperative period at PACU.
Keywords: acute; colorectal cancer; dexmedetomidine; laparoscopic; postoperative pain
Methods: We retrospectively analyzed data for 143 patients who had undergone laparoscopic colorectal cancer surgery with intraoperative continuous dexmedetomidine injection (0.5 atients were categorized into the DEX group and non-DEX group, respectively. The demographic, clinical, anesthetic data, and pain at postoperative anesthesia care unit (PACU), 1, 2, and 3 days after surgery were compared between the groups.
Results: A total of 119 patients were enrolled. Demographic and clinical data were not different between the groups. Intraoperatively, mean arterial pressure, heart rate, minimum alveolar concentration of sevoflurane, and fentanyl consumption were significantly lower in DEX group. At PACU, pain score and fentanyl consumption were significantly lower in DEX group. Postoperatively, pain scores and opioid consumptions at 1, 2, and 3 days after surgery were not different between the groups. Time to pass flatus, length of hospital stay, and incidence of nausea/vomiting, and itching were not different between the groups.
Conclusion: Intraoperative continuous dexmedetomidine injection showed intraoperative analgesic effect which was supposed by lower mean arterial pressure, heart rate, minimum alveolar concentration of sevoflurane, and fentanyl consumption. However, it did not have analgesic effect during acute postoperative period except postoperative period at PACU.
Keywords: acute; colorectal cancer; dexmedetomidine; laparoscopic; postoperative pain